Wednesday, December 8, 2010

Möbius fold ? Human apolipoprotein A-I

The structure of truncated human apolipoprotein A-I (PDB code 1AV1) is the major protein component of high density lipoprotein. High-density lipoprotein (HDL) is one of the five major groups of lipoproteins which, in order of sizes, largest to smallest, are chylomicrons, VLDL, IDL, LDL and HDL, which enable lipids like cholesterol and triglycerides to be transported within the blood stream.
The molecule consists almost entirely of a pseudo-continuous, amphipathic alpha-helix that is punctuated by kinks at regularly spaced proline residues; it adopts a shape similar to a horseshoe of dimensions 12.5 x 8.0 x 4.0 nanometers. Four molecules in the asymmetric unitassociate via their hydrophobic faces to form an antiparallel four-helix bundle with an elliptical ring shape.


  1. Wow, that's amazing! Is this its conformational state? So cool.

  2. Hi there,

    You may know this already but the MolBio carnival is up over at my blog, Ruleof6ix: Your post(s) were featured on it! Hope you enjoy it, also if you could promote/spread the word for this carnival for future submissions it would be great. Thanks for submitting.

    I encourage you to submit to the next edition. The next edition will be out at
    hosted by E.E. Giorgi and it'll be on the first Monday in January.

    Kind regards,


  3. I am glad that I saw this post. It is informative blog for us and we need this type of blog thanks for share this blog, Keep posting such instructional blogs and I am looking forward for your future posts.ฉีด หน้า เรียว

  4. A huge shout out to the writer who poured his soul into this blog.