Sunday, January 30, 2011

Molybdenum cofactor biosynthesis protein MoaC.



The molybdenum cofactor (Moco) is an essential component of a large family of enzymes involved in important transformations in carbon, nitrogen and sulfur metabolism. The Moco biosynthetic pathway is evolutionarily conserved and found in archaea, eubacteria and eukaryotes. In humans, genetic deficiencies of enzymes involved in thispathway trigger an autosomal recessive and usually deadly disease with severe neurological symptoms. The MoaC protein,together with the MoaA protein, is involved in the first step of Moco biosynthesis. (from paper abstract)
Wuebbens et al. Structure Fold.Des. 8: 709-717

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  1. Enzymes have got to be some of the most amazing things in nature. They are, in many respects, nano-sized machines. They show down to the molecular level just how highly coordinated and mind-bogglingly complex the systems in our bodies are, and yet confirm they are a product of, and vassal to, the basic laws of chemistry and physics. The fact that they are so tuned to their jobs is also amazing: a single atom of the metal molybdenum is required for this enzyme to operate, and nothing else will do. Incredible.

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